In the monkeypox outbreak that unspooled this summer in the United States and dozens of other countries, men who have sex with men were the most at risk. But thousands of women were also infected, and many more cases were probably missed, according to the first ever study of women and nonbinary people who had contracted the disease.
As in men, sexual contact was most likely to be the source of infection among transgender women, accounting for 89 percent of cases, according to the case series, published on Thursday in the journal Lancet. But among cisgender women and nonbinary individuals who were assigned female at birth, only 61 percent of cases could be connected to sexual contact.
Nearly one-quarter of cisgender women in the study might have been infected without sexual interaction with an infected person, said Dr. Chloe Orkin, a physician and researcher at Queen Mary University of London. The women were thought to have been infected through exposure at their jobs or homes or through other types of close contact.
“The lesson here is that everybody needs to know about this,” Dr. Orkin said. While it’s appropriate that public health messages have mostly been directed at men who have sex with men, she added, “it’s important to recognize this is not the only group.”
After several months of rapidly escalating case numbers, the monkeypox outbreak in the United States has slowed, thanks in part to a vaccination campaign and changes in the behavior of many high-risk individuals. Since May, there have been just over 29,000 cases in the United States, but only about a thousand cases have been diagnosed in the last month.
Yet as the disease fades from public attention, scientists are just beginning to understand when and how it spreads and who is at risk.
In the new study, Dr. Orkin and her colleagues found genetic material from the monkeypox virus in all 14 of the vaginal swabs they tested, suggesting that the virus can be transmitted through genital secretions. Studies in men have similarly found the virus in seminal fluid.
Still, public health authorities have hesitated to call monkeypox a sexually transmitted infection, arguing that the virus can spread through close physical contact of any kind.
But some experts disagree: The fact that monkeypox can be transmitted in other ways should not preclude its classification as a sexually transmitted disease, because other diseases like herpes and syphilis can also spread through nonsexual close contact, some have said.
Last month, New York State added monkeypox to its list of sexually transmitted infections, but the Centers for Disease Control and Prevention has not made that change. The agency will leave that categorization up to individual states, said Dr. Demetre Daskalakis, deputy coordinator of the White House’s monkeypox response. But it’s clear that sexual behavior drives cases, he said.
What to Know About the Monkeypox Virus
Card 1 of 7
What is monkeypox? Monkeypox is a virus similar to smallpox, but symptoms are less severe. It was discovered in 1958, after outbreaks occurred in monkeys kept for research. The virus was primarily found in parts of Central and West Africa, but recently it has spread to dozens of countries and infected tens of thousands of people, overwhelmingly men who have sex with men.
How does it spread? The monkeypox virus can spread from person to person through close physical contact with infectious lesions or pustules, by touching items — like clothing or bedding — that previously touched the rash, or via the respiratory droplets produced by coughing or sneezing. Monkeypox can also be transmitted from mother to fetus via the placenta or through close contact during and after birth.
I fear I might have monkeypox. What should I do? There is no way to test for monkeypox if you have only flulike symptoms. But if you start to notice red lesions, you should contact an urgent care center or your primary care physician, who can order a monkeypox test. Isolate at home as soon as you develop symptoms, and wear high-quality masks if you must come in contact with others for medical care.
I live in New York. Can I get the vaccine? Adult men who have sex with men and who have had multiple sexual partners in the past 14 days are eligible for a vaccine in New York City, as well as close contacts of infected people. Eligible people who have conditions that weaken the immune system or who have a history of dermatitis or eczema are also strongly encouraged to get vaccinated. People can book an appointment through this website.
“If you took sex away, would we have had a monkeypox outbreak? Probably not,” he added. Even if the primary reason for the spread is skin-to-skin contact during sexual activity, “it’s definitely a sexually associated transmission.”
This year, Dr. Orkin led an international collaboration to characterize monkeypox symptoms in 500 patients. The findings led Britain, the United States and other countries to refine their case definitions of the disease.
And last month, the U.K. Health Security Agency published a study suggesting that between about 40 percent and 60 percent of monkeypox transmission may occur before infected people develop symptoms.
This makes sense intuitively because once patients develop the painful blisters, they would be unlikely to have sex, noted Tom Ward, an infectious disease modeler for the agency. Some small percentage of infected people may never develop symptoms, he said.
Tracing contacts in a monkeypox outbreak is extremely challenging because of the sensitive and often anonymous nature of spread; there are no tests that can detect monkeypox before the characteristic skin rash appears.
“What it essentially highlights is that we still need a lot of research into the nature of asymptomatic and pre-symptomatic transmission of monkeypox,” Dr. Ward said.
Some people may have mild, generic symptoms like a sore throat before developing the rash.
Those individuals should stay home to protect others, Dr. Daskalakis said. But ultimately, he said, the possibility of pre-symptomatic spread doesn’t change the public health message to people at risk: immunization against monkeypox.
“Probably the strongest guidance is that if there is past history that would make you think that you’re at risk for monkeypox, it’s important to get vaccinated, and if there’s a potential for future risk, it’s important to get vaccinated,” he added.
The new study is the first to describe monkeypox in transgender or nonbinary people, who often have little access to quality health care and are rarely included in research studies.
“It’s very, very important that we report on both sex and gender differences, because both are important, and in some cases, they intersect,” Dr. Orkin said.
In the study, researchers from 15 countries contributed clinical information from 69 cisgender women, 62 transgender women and five nonbinary individuals who were diagnosed with monkeypox between May 11 and Oct. 4. About 45 percent of the women were Latino, 29 percent were white and 21 percent were Black.
More than half the patients in the study had sores in their anus, genitals, mouth or eyes. But some women — especially cisgender women — were initially misdiagnosed with other sexually transmitted infections.
Experts had anticipated that monkeypox “would have probably a slightly different pattern of transmission depending on social behaviors and norms within certain groups,” said Dr. Abraar Karan, an infectious diseases physician at Stanford University.
The new study supported that inference. In contrast with male monkeypox patients who have sex with men, only 7 percent of the patients in the study reported having attended a Pride event or other similar gatherings. While the transgender women in the study had had about 10 partners on average over the previous month, the cisgender women had one, and 7 percent of the cisgender women said they had no sexual partners in the previous month.
“So the driver was not the same,” Dr. Karan said.
Many of the transgender women in the study had other risk factors for monkeypox, including undiagnosed and untreated H.I.V., homelessness and injection drug use. Half of the transgender women in the study had H.I.V. compared with 8 percent of the cisgender women, and more than half of the transgender women were engaged in commercial sex work compared with 3 percent of cisgender women.
“Even though the absolute number of people who are trans and engaged in sex work may not be very large, the extremely high prevalence of H.I.V. and now monkeypox and other sexually transmitted infections means that public health agencies need to be thinking of ways to do outreach in this population,” said Dr. Jay Varma, director of the Cornell Center for Pandemic Prevention and Response.
While many of the transgender women sought care at sexual health clinics, the cisgender women in the study went to primary care providers or to emergency departments, where doctors were more likely to be unfamiliar with monkeypox symptoms. About one in three cisgender women were diagnosed late or with another disease; some were probably never diagnosed.
“It’s very likely that infections have been missed and not picked up at all,” Dr. Orkin said.
About one in four of the cisgender women in the study lived with children, but the doctors identified only two cases of monkeypox among them. The C.D.C.’s observations jibe with that finding.
But Dr. Karan cautioned that cases in children might be under reported because of the stigma associated with monkeypox. More studies are needed to understand how symptoms may vary in different populations, particularly in countries where the virus has caused outbreaks for years, he said.